Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ethylamine | HCID 6341 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 4,6-Dichloro-5-nitro-2-(propan-2-yl)pyrimidine | HCID 12320334 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 21400867 | HCID 21400867 | 92% |
Reaction Steps
4.72 g (0.02 mol) of 4,6-dichloro-2-isopropyl-5-nitro-pyrimidine are dissolved in 100 ml of abs. ethanol. At -30° C, 2 g (0.02 mol) of triethylamine and 0.9 g (0.02 mol) of ethylamine are added and the mixture is then stirred for 4 hours at -20° C and for 6 hours at 0° C. Subsequently the reaction mixture is concentrated to dryness and the product is taken up in water and extracted with ether, to yield 4.5 g of 2-isopropyl-4-ethylamino-5-nitro-6-chloro-pyrimidine; m.p. 50° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US04055411 |
|---|
| Source dataset | uspto-grants-1977_10 |
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| ORD ID | ord-c38d824e69884a81884e1e264b394bff |
|---|
| Source note | uspto-grants-1977_10 |
|---|
