Ethylamine → HCID 21400867, compound

HRID 973120Notes

Reaction equation

HRID 973120 reaction equation
Cl[C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[C:6]([Cl:11])[N:5]=[C:4]([CH:12]([CH3:14])[CH3:13])[N:3]=1.[CH2:15]([N:17](CC)CC)[CH3:16].C(N)C>C(O)C>[CH:12]([C:4]1[N:3]=[C:2]([NH:17][CH2:15][CH3:16])[C:7]([N+:8]([O-:10])=[O:9])=[C:6]([Cl:11])[N:5]=1)([CH3:14])[CH3:13]

Participants

5

Reactant 3

HCID 6341EthylamineHCID 8471TriethylamineHCID 123203344,6-Dichloro-5-nitro-2-(propan-2-yl)pyrimidine

Product 1

HCID 21400867HCID 21400867, compoundYield 92%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
0 °C

Procedure

4.72 g (0.02 mol) of 4,6-dichloro-2-isopropyl-5-nitro-pyrimidine are dissolved in 100 ml of abs. ethanol. At -30° C, 2 g (0.02 mol) of triethylamine and 0.9 g (0.02 mol) of ethylamine are added and the mixture is then stirred for 4 hours at -20° C and for 6 hours at 0° C. Subsequently the reaction mixture is concentrated to dryness and the product is taken up in water and extracted with ether, to yield 4.5 g of 2-isopropyl-4-ethylamino-5-nitro-6-chloro-pyrimidine; m.p. 50° C.

Workup

  1. concentrationSubsequently the reaction mixture is concentrated to dryness
  2. extractionextracted with ether

Sources & evidence

ORD record
ord-c38d824e69884a81884e1e264b394bff
Source dataset
uspto-grants-1977_10
Patent number
US04055411

Reaction notes

Loading…