Ethylamine → HCID 68122832, compound

HRID 973121Notes

Reaction equation

HRID 973121 reaction equation
Cl[C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[C:6](Cl)[N:5]=[C:4]([C:12]([F:15])([F:14])[F:13])[N:3]=1.C([N:18]([CH2:21][CH3:22])CC)C.[CH2:23]([NH2:25])[CH3:24]>C(O)C>[CH2:23]([NH:25][C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[C:6]([NH:18][CH2:21][CH3:22])[N:5]=[C:4]([C:12]([F:15])([F:14])[F:13])[N:3]=1)[CH3:24]

Participants

5

Reactant 3

HCID 6341EthylamineHCID 8471TriethylamineHCID 214008694,6-Dichloro-5-nitro-2-(trifluoromethyl)pyrimidine

Product 1

HCID 68122832HCID 68122832, compoundYield 98.5%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

5.25 g (0.02 mol) of 4,6-dichloro-5-nitro-2-trifluoromethyl-pyrimidine (J. Org. Chem. 26 (1961), pp. 4504-8) are dissolved in 150 ml of abs. ethanol. The solution is treated with 5 ml of triethylamine (0.05 mol) and 4.5 g (0.1 mol) of ethylamine and the mixture is stirred overnight, then evaporated to dryness. The residue is taken up in ether and washed with water. The ethereal phase is dried and concentrated to yield 5.5 g of 4,6-bis-ethylamino-5-nitro-2-trifluoromethyl-pyrimidine; m.p. 60°-65° C.

Workup

  1. dissolution4504-8) are dissolved in 150 ml of abs
  2. customevaporated to dryness
  3. washwashed with water
  4. customThe ethereal phase is dried
  5. concentrationconcentrated

Sources & evidence

ORD record
ord-4d8667de238e48dc9ca1cb45d690dc9e
Source dataset
uspto-grants-1977_10
Patent number
US04055411

Reaction notes

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