Methanol → HCID 131725893, compound

HRID 9732Notes

Reaction equation

HRID 9732 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N:8]1[CH2:17][C:16]2[C:11](=[N:12][C:13]([NH:18][C:19]3[CH:30]=[CH:29][C:22]4[N:23]([CH3:28])[C:24](=[O:27])[CH2:25]S[C:21]=4[CH:20]=3)=[N:14][CH:15]=2)[N:10]([CH3:31])[C:9]1=[O:32].OO[S:35]([O-:37])=O.[K+].[CH3:39]O>>[Br:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N:8]1[CH2:17][C:16]2[C:11](=[N:12][C:13]([NH:18][C:19]3[CH:30]=[CH:29][C:22]4[N:23]([CH3:28])[C:24]([O:25][CH3:39])=[CH:27][S:35](=[O:37])[C:21]=4[CH:20]=3)=[N:14][CH:15]=2)[N:10]([CH3:31])[C:9]1=[O:32]

Participants

4

Reactant 3

HCID 887MethanolHCID 104814663-(2-Bromo-phenyl)-1-methyl-7-(4-methyl-3-oxo-3,4-dihydro-2h-benzo[1,4]thiazin-7-ylamino)-3,4-dihydro-1h-pyrimido[4,5-d]pyrimidin-2-oneHCID 23707502Potassium hydroxy sulfite

Product 1

HCID 131725893HCID 131725893, compound

Procedure

100 mg of the compound from example 9 and 108 mg oxone were stirred in 2 ml MeOH at room temperature for 17 hrs. The mixture was filtered and the residue washed with THF. The combined filtrates were concentrated and purified by preparative HPLC-MS to yield 10 mg of the title compound.

Workup

  1. filtrationThe mixture was filtered
  2. washthe residue washed with THF
  3. concentrationThe combined filtrates were concentrated
  4. custompurified by preparative HPLC-MS

Sources & evidence

ORD record
ord-3217fe884c024c1793d25f2ce03d4619
Source dataset
uspto-grants-2006_08
Patent number
US07091345B2

Reaction notes

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