反应详情

A mixture of 2-[4-(4-chlorophenyl)benzyloxy]-3,3,3-trifluoro-2-trifluoromethylpropionic acid (3.0 g.), thionyl chloride (3.0 ml.), dimethylformamide (0.16 g.) and benzene (10 ml.) is heated under reflux until the solution becomes turbid (ca. 10 minutes). The mixture is evaporated in vacuo, benzene (10 ml.) is added and the evaporation is repeated. Light petroleum (10 ml., b.p. 40°-60° C.) is added to the residue, and the solution is separated from insoluble oils and evaporated to give 2-[4-(4-chlorophenyl)benzyloxy]-3,3,3-trifluoro-2-trifluoromethylpropionyl chloride (3.07 g.), m.p. 30°-35° C.

1. temperatureis heated
2. temperatureunder reflux until the solution
3. customturbid (ca. 10 minutes)
4. customThe mixture is evaporated in vacuo, benzene (10 ml.)
5. additionis added
6. customthe evaporation
7. additionLight petroleum (10 ml., b.p. 40°-60° C.) is added to the residue
8. customthe solution is separated from insoluble oils
9. customevaporated