HCID 13384229, compound → HCID 13384230, compound

HRID 973313Notes

Reaction equation

HRID 973313 reaction equation
Cl[C:2]1[CH:22]=[CH:21][C:5]([O:6][C:7]([C:17]([F:20])([F:19])[F:18])([C:13]([F:16])([F:15])[F:14])[C:8]([O:10]CC)=[O:9])=[CH:4][CH:3]=1.O(C(C(F)(F)F)(C(F)(F)F)C(OCC)=O)C1C=CC=CC=1>>[O:6]([C:7]([C:13]([F:14])([F:15])[F:16])([C:17]([F:18])([F:19])[F:20])[C:8]([OH:10])=[O:9])[C:5]1[CH:4]=[CH:3][CH:2]=[CH:22][CH:21]=1

Participants

3

Reactant 2

HCID 13384229HCID 13384229, compoundHCID 13384231HCID 13384231, compound

Product 1

HCID 13384230HCID 13384230, compound

Procedure

The above process is repeated except that the ethyl 2-(4-chlorophenoxy)-3,3,3-trifluoro-2-trifluoromethylpropionate is replaced by ethyl 2-phenoxy-3,3,3-trifluoro-2-trifluoromethylpropionate (13 g.) and the residue obtained by evaporation of the ethereal extract is purified by distillation at 10-3 mm. pressure, crystallisation from petrol (b.p. 30°-40° C.) at -65° C. and redistillation to give 2-phenoxy-3,3,3-trifluoro-2-trifluoromethylpropionic acid, b.p. 68°-70° C, at 10-3 mm., m.p. 6°-8° c. (8 g.).

Workup

  1. customthe residue obtained by evaporation of the ethereal
  2. extractionextract
  3. distillationis purified by distillation at 10-3 mm
  4. custompressure, crystallisation from petrol (b.p. 30°-40° C.) at -65° C.
  5. distillationredistillation

Sources & evidence

ORD record
ord-832743ebe8d744fb8ad117b681521eeb
Source dataset
uspto-grants-1977_10
Patent number
US04055595

Reaction notes

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