Formic Acid → 8-Carbamoyl-12-formyloxyheptadecanoic acid

Participants

Reaction Conditions

Reaction Steps

A mixture of 8-carbamoyl-12-hydroxyheptadecanoic acid (8.2 g., 0.025 mole) (Example 1, Step F) and 97% formic acid (10 ml.) is heated at 60° C. for 24 hours. The mixture is cooled, dissolved in 100 ml. ether, washed with 3 portions of water and dried over sodium sulfate. Evaporation of the ether leaves the product 8-carbamoyl-12-formyloxyheptadecanoic acid as a slightly yellowish viscous oil.

Provenance & Evidence