Hydrochloric Acid → HCID 53813383, compound

HRID 973370Notes

Reaction equation

HRID 973370 reaction equation
[Cl:1][C:2]1[CH:12]=[CH:11][C:10]([N+:13]([O-:15])=[O:14])=[CH:9][C:3]=1[CH:4]=[CH:5][C:6]([OH:8])=[O:7].Cl.[C:17]([O-])(O)=O.[Na+].O>CO.C(Cl)Cl>[Cl:1][C:2]1[CH:12]=[CH:11][C:10]([N+:13]([O-:15])=[O:14])=[CH:9][C:3]=1[CH:4]=[CH:5][C:6]([O:8][CH3:17])=[O:7]

Participants

6

Reactant 3

HCID 313Hydrochloric Acid2×HCID 605982HCID 605982, compoundHCID 86585896Sodium bicarbonate water

Product 1

HCID 53813383HCID 53813383, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 6344DichloromethaneSolvent

Procedure

A solution of 34.1 g (150 millimoles) of the product from Example 1 in 300 ml of methanol was saturated with HCl gas, after which further HCl gas was passed in during the reaction time of 5 hours. The solid obtained on cooling was stirred thoroughly with NaHCO3 /water and taken up in methylene chloride. The CH2Cl2 solution was washed with water and dried over MgSO4, and the abovementioned product was obtained by evaporating down the solution and triturating the residue with diethyl ether. Yield: 24 g (63%); mp. 159°-162° C.

Workup

  1. customwas passed in during the reaction time of 5 hours
  2. customThe solid obtained
  3. temperatureon cooling
  4. washThe CH2Cl2 solution was washed with water
  5. dry with materialdried over MgSO4
  6. customthe abovementioned product was obtained
  7. customby evaporating down the solution
  8. customtriturating the residue with diethyl ether

Sources & evidence

ORD record
ord-7061c7fa00b34701bbbe17be5fa9542c
Source dataset
uspto-grants-1991_11
Patent number
US05062884

Reaction notes

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