Hydrochloric Acid → HCID 19989834, compound

HRID 973397Notes

Reaction equation

HRID 973397 reaction equation
[NH2:1][C:2]1[C:11]2[C:6](=[CH:7][C:8]([C:12]3[CH:13]([CH3:19])[CH2:14][C:15](=[O:18])[NH:16][N:17]=3)=[CH:9][CH:10]=2)[N:5]=[CH:4][N:3]=1.[ClH:20]>>[OH2:18].[ClH:20].[NH2:1][C:2]1[C:11]2[C:6](=[CH:7][C:8]([C:12]3[CH:13]([CH3:19])[CH2:14][C:15](=[O:18])[NH:16][N:17]=3)=[CH:9][CH:10]=2)[N:5]=[CH:4][N:3]=1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 15079122HCID 15079122, compound

Product 1

HCID 19989834HCID 19989834, compoundYield 54%

Procedure

Compound 11 (0.34 g) obtained in Example 11 was dissolved with heating in 10 ml of 1N hydrochloric acid. The solution was cooled, and the crystals precipitated were collected by filtration and dried to give 0.21 g (54%) of 6-(4-aminoquinazolin-7-yl)-4,5-dihydro-5-methyl3(2H)-pyridazinone monohydrochloride monohydrate (Compound 11').

Workup

  1. temperatureThe solution was cooled
  2. customthe crystals precipitated
  3. filtrationwere collected by filtration
  4. customdried

Sources & evidence

ORD record
ord-daf1ffbb720e476691d96f2efbfa66d0
Source dataset
uspto-grants-1991_11
Patent number
US05063227

Reaction notes

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