反应详情

温度

0 °C

4-Amino-5-chlorosalicylic acid (24 g) is added to a stirred solution of thionyl chloride (30 ml) in methanol (300 ml) cooled to 0° C., and the mixture is stirred under reflux for 18 hours. The reaction mixture is evaporated and the residue is recrystallized from EtOH-H2O to give methyl 4-amino-5-chlorosalicylate which is used directly in the next step.

1. temperatureunder reflux for 18 hours
2. customThe reaction mixture is evaporated
3. customthe residue is recrystallized from EtOH-H2O