HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 973412Generated: October 30, 2026
Methanol → Methyl 4-amino-5-chloro-2-hydroxybenzoate
https://huagongshe.com/reaction/973412
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 4-Amino-5-chloro-2-hydroxybenzoic acid | HCID 14883222 | — |
| Product | Methyl 4-amino-5-chloro-2-hydroxybenzoate | HCID 14883223 | — |
Reaction Steps
4-Amino-5-chlorosalicylic acid (24 g) is added to a stirred solution of thionyl chloride (30 ml) in methanol (300 ml) cooled to 0° C., and the mixture is stirred under reflux for 18 hours. The reaction mixture is evaporated and the residue is recrystallized from EtOH-H2O to give methyl 4-amino-5-chlorosalicylate which is used directly in the next step.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05063230 |
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| Source dataset | uspto-grants-1991_11 |
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| ORD ID | ord-95dbf6147f4842b68bb42b79d713667b |
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| Source note | uspto-grants-1991_11 |
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