HCID 14330456, compound → 5-Methoxy-3,4-dihydro-2H-1-benzothiopyran-3-amine

HRID 973430Notes

Reaction equation

HRID 973430 reaction equation
C(OC([NH:8][CH:9]1[CH2:14][C:13]2[C:15]([O:19][CH3:20])=[CH:16][CH:17]=[CH:18][C:12]=2[S:11][CH2:10]1)=O)(C)(C)C>FC(F)(F)C(O)=O>[CH3:20][O:19][C:15]1[C:13]2[CH2:14][CH:9]([NH2:8])[CH2:10][S:11][C:12]=2[CH:18]=[CH:17][CH:16]=1

Participants

3

Reactant 1

HCID 14330456HCID 14330456, compound

Product 1

HCID 143304585-Methoxy-3,4-dihydro-2H-1-benzothiopyran-3-amine

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

A solution of 10 g of N-t-butoxycarbonyl-3,4-dihydro-5-methoxy-2H-[1]-benzothiopyran-3-amine in 30 ml of trifluoroacetic acid is kept at room temperature for 1 hour. The solvent is removed in vacuo, the residue is treated with 1N NaOH and the product is extracted with ether. After drying over magnesium sulfate, the solvent is removed in vacuo to afford 3,4-dihydro-5-methoxy-2H[1]-benzothiopyran-3-amine as an oil.

Workup

  1. customThe solvent is removed in vacuo
  2. additionthe residue is treated with 1N NaOH
  3. extractionthe product is extracted with ether
  4. dry with materialAfter drying over magnesium sulfate
  5. customthe solvent is removed in vacuo

Sources & evidence

ORD record
ord-3ea8b1dfef0c4ccfa84dfd00cdd06fc4
Source dataset
uspto-grants-1991_11
Patent number
US05063233

Reaction notes

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