Benzyl (2R)-2-Benzyl-3-(4-trifluoroethylpiperazin-1-ylcarbonyl)propionate → (2R)-2-Benzyl-3-(4-trifluoroethylpiperazine-1-ylcarbonyl)propionic Acid

HRID 973499Notes

Reaction equation

HRID 973499 reaction equation
[CH2:1]([C@H:8]([CH2:19][C:20]([N:22]1[CH2:27][CH2:26][N:25]([CH2:28][C:29]([F:32])([F:31])[F:30])[CH2:24][CH2:23]1)=[O:21])[C:9]([O:11]CC1C=CC=CC=1)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>[Pd].CO>[CH2:1]([C@H:8]([CH2:19][C:20]([N:22]1[CH2:23][CH2:24][N:25]([CH2:28][C:29]([F:32])([F:30])[F:31])[CH2:26][CH2:27]1)=[O:21])[C:9]([OH:11])=[O:10])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 1

HCID 15018098Benzyl (2R)-2-Benzyl-3-(4-trifluoroethylpiperazin-1-ylcarbonyl)propionate

Product 1

HCID 15018099(2R)-2-Benzyl-3-(4-trifluoroethylpiperazine-1-ylcarbonyl)propionic AcidYield 96.4%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

The resultant compound from Example 24 (610 mg), and 10% palladium on carbon (300 mg) in methanol were stirred under an H2 atmosphere for 2 h. Filtration and solvent evaporation afforded 470 mg (96%) of a solid, m.p. 96°-98° C.

Workup

  1. filtrationFiltration and solvent evaporation

Sources & evidence

ORD record
ord-55aebaba65654326b4914ec1540ca9fd
Source dataset
uspto-grants-1991_11
Patent number
US05063208

Reaction notes

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