HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzyl (2R)-2-Benzyl-3-(4-trifluoroethylpiperazin-1-ylcarbonyl)propionate → (2R)-2-Benzyl-3-(4-trifluoroethylpiperazine-1-ylcarbonyl)propionic Acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzyl (2R)-2-Benzyl-3-(4-trifluoroethylpiperazin-1-ylcarbonyl)propionate | HCID 15018098 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | (2R)-2-Benzyl-3-(4-trifluoroethylpiperazine-1-ylcarbonyl)propionic Acid | HCID 15018099 | 96.4% |
Reaction Steps
The resultant compound from Example 24 (610 mg), and 10% palladium on carbon (300 mg) in methanol were stirred under an H2 atmosphere for 2 h. Filtration and solvent evaporation afforded 470 mg (96%) of a solid, m.p. 96°-98° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05063208 |
| Source dataset | uspto-grants-1991_11 |
| ORD ID | ord-55aebaba65654326b4914ec1540ca9fd |
| Source note | uspto-grants-1991_11 |