Methylamine → HCID 19988719, compound

HRID 973575Notes

Reaction equation

HRID 973575 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[NH:8][C:9]1[N:18]=[C:17]([Cl:19])[C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[N:10]=1.[CH3:20][NH2:21]>C(O)C>[ClH:19].[CH3:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[NH:8][C:9]1[N:18]=[C:17]([NH:21][CH3:20])[C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[N:10]=1

Participants

4

Reactant 2

HCID 6329MethylamineHCID 10333315HCID 10333315, compound

Product 1

HCID 19988719HCID 19988719, compoundYield 8.9%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

2-(2-methylphenylamino)-4-chloroquinazoline (2 g, 0.0065 mol) and methylamine in ethanol (33%, 30 ml) were placed in a pressure vessel and heated for 4 hours at 140°. After cooling, the reaction mixture was evaporated to dryness. The residue afforded crystals of 2-(2-methylphenylamino)-4-methylaminoquinazoline hydrochloride (0.29 g, 8.9%) from ethanolic hydrogen chloride, m.p. 275°-279°.

Workup

  1. temperatureheated for 4 hours at 140°
  2. temperatureAfter cooling
  3. customthe reaction mixture was evaporated to dryness

Sources & evidence

ORD record
ord-ee915c2e75474302bff2ed1067ca1672
Source dataset
uspto-grants-1991_11
Patent number
US05064833

Reaction notes

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