反应详情

A mixture of 2-chloro-4-(N-methylphenylamino)-6methoxyquinazoline (5.4 g, 0.027M), o-toluidine (4.28 g, 0.04M) in ethanol (50 ml) was heated in a Berchof pressure vessel at 140° for 5 hours (maximum pressure 40 psi). After cooling, ethanol/HCl was added and the solid which crystallised out was filtered off and recrystallised from isopropanol/ether to yield the title compound (4.23 g, m.p. 258°-260°).

1. temperaturewas heated in a Berchof pressure vessel at 140° for 5 hours (maximum pressure 40 psi)
2. temperatureAfter cooling
3. customthe solid which crystallised out
4. filtrationwas filtered off
5. customrecrystallised from isopropanol/ether