HuagongsheHuagongshe Chemistry Print Report · For research reference only
O-Toluidine → 4-(N-methylphenylamino)-2-(2-methylphenylamino)-6-methoxyquinazoline hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | O-Toluidine | HCID 7242 | — |
| Reactant | 2-Chloro-4-(N-methylphenylamino)-6-methoxyquinazoline | HCID 10086138 | — |
| Reactant | Ethanol hydrochloride | HCID 21887872 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 4-(N-methylphenylamino)-2-(2-methylphenylamino)-6-methoxyquinazoline hydrochloride | HCID 67925966 | 57.7% |
Reaction Steps
A mixture of 2-chloro-4-(N-methylphenylamino)-6methoxyquinazoline (5.4 g, 0.027M), o-toluidine (4.28 g, 0.04M) in ethanol (50 ml) was heated in a Berchof pressure vessel at 140° for 5 hours (maximum pressure 40 psi). After cooling, ethanol/HCl was added and the solid which crystallised out was filtered off and recrystallised from isopropanol/ether to yield the title compound (4.23 g, m.p. 258°-260°).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05064833 |
| Source dataset | uspto-grants-1991_11 |
| ORD ID | ord-f4874eb13583451e8289090777161ac8 |
| Source note | uspto-grants-1991_11 |