HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 4-(N-Methylphenylamino)-2-(2-methyl-4-fluorophenylamino)-6-methoxyquinazoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 4-Fluoro-2-methylaniline | HCID 67982 | — |
| Reactant | 2-Chloro-4-(N-methylphenylamino)-6-methoxyquinazoline | HCID 10086138 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 4-(N-Methylphenylamino)-2-(2-methyl-4-fluorophenylamino)-6-methoxyquinazoline | HCID 10249676 | 54.3% |
Reaction Steps
2-Chloro-4-(N-methylphenylamino)-6-methoxyquinazoline (5.4 g, 0.02M) and 4-fluoro-2-methylaniline (4.96 g, 0.04M) were dissolved in ethanol (50 ml) and heated at 140° for 5 hours in a Berghof pressure reactor. The mixture was cooled and ethereal/HCl added. The precipitated solid was filtered off and recrystallised (isopropanol/ether followed by isopropanol) to yield the title compound (3.8 g) m.p. 248°-250°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05064833 |
| Source dataset | uspto-grants-1991_11 |
| ORD ID | ord-d078d3e282ec4b898f264c21c6715b45 |
| Source note | uspto-grants-1991_11 |