反应详情

2-Chloro-4-(N-methylphenylamino)-6-methoxyquinazoline (5.4 g, 0.02M) and 4-fluoro-2-methylaniline (4.96 g, 0.04M) were dissolved in ethanol (50 ml) and heated at 140° for 5 hours in a Berghof pressure reactor. The mixture was cooled and ethereal/HCl added. The precipitated solid was filtered off and recrystallised (isopropanol/ether followed by isopropanol) to yield the title compound (3.8 g) m.p. 248°-250°.

1. temperatureheated at 140° for 5 hours in a Berghof pressure reactor
2. temperatureThe mixture was cooled
3. filtrationThe precipitated solid was filtered off
4. customrecrystallised (isopropanol/ether followed by isopropanol)