Hydrochloric Acid → Hydrochloric Acid

HRID 973601Notes

Reaction equation

HRID 973601 reaction equation
[NH2:1][CH2:2][CH2:3][CH2:4][P:5]([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)(=[O:7])[OH:6].[ClH:14].[H][H]>O>[NH2:1][CH2:2][CH2:3][CH2:4][P:5]([CH:8]1[CH2:13][CH2:12][CH2:11][CH2:10][CH2:9]1)(=[O:6])[OH:7].[ClH:14]

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 101042063-Aminopropyl(phenyl)phosphinic acidHCID 178418361HCID 178418361, compound2×

Product 2

HCID 313Hydrochloric AcidHCID 99207013-Aminopropyl(cyclohexyl)phosphinic acid

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture of 1.5 g of 3-aminopropyl(phenyl)phosphinic acid in 10 ml of water and 7.9 of 1 N hydrochloric acid is treated with hydrogen at 25° in the presence of 0.2 g of Nishimura-catalyst (Rh/PtO2. After 1.2 hours hydrogen up-take stops. The reaction mixture is filtered and the filtrate evaporated to dryness. The residue is recrystallized from methanol/propylenoxide to give 1.2 g of 3-aminopropyl(cyclohexyl)-phosphinic acid×0,4 mol hydrochloric acid as a white solid, m.p. 202°-203°.

Workup

  1. filtrationThe reaction mixture is filtered
  2. customthe filtrate evaporated to dryness
  3. customThe residue is recrystallized from methanol/propylenoxide

Sources & evidence

ORD record
ord-f343fe1c1fe343ec8b0010dbf436f7f9
Source dataset
uspto-grants-1991_11
Patent number
US05064819

Reaction notes

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