Ammonia → HCID 19090926, compound

HRID 973618Notes

Reaction equation

HRID 973618 reaction equation
[C:1]([CH2:3][CH2:4][P:5]([CH:10]([O:15][CH2:16][CH2:17][CH3:18])[O:11][CH2:12][CH2:13][CH3:14])(=[O:9])[O:6][CH2:7][CH3:8])#[N:2].N>C(O)C.[Ni]>[NH2:2][CH2:1][CH2:3][CH2:4][P:5]([CH:10]([O:15][CH2:16][CH2:17][CH3:18])[O:11][CH2:12][CH2:13][CH3:14])(=[O:9])[O:6][CH2:7][CH3:8]

Participants

5

Reactant 2

HCID 222AmmoniaHCID 19090879HCID 19090879, compound

Product 1

HCID 19090926HCID 19090926, compound

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 702EthanolSolvent

Procedure

A mixture of 4,35 g of ethyl 2-cyanoethyl(di-n-propyloxymethyl)phosphinate, 10 g of ammonia and 2.3 g of Raney-Nickel in 170 ml of ethanol is hydrogenated for 10.5 hours. The catalyst is filtered off and the solvent is removed by evaporation. The crude oil is purified by distillation to yield ethyl 3-aminopropyl(di-n-propyloxymethyl)phosphinate as a colourless oil.

Workup

  1. filtrationThe catalyst is filtered off
  2. customthe solvent is removed by evaporation
  3. distillationThe crude oil is purified by distillation

Sources & evidence

ORD record
ord-d05c6116d4a4499c99bbd178414b334d
Source dataset
uspto-grants-1991_11
Patent number
US05064819

Reaction notes

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