HCID 131717066, compound → HCID 178441828, compound

HRID 973665Notes

Reaction equation

HRID 973665 reaction equation
[NH2:1][C:2]1[N:3]=[C:4]([CH2:48][CH2:49][CH2:50][CH3:51])[N:5]([CH2:11][C:12]2[CH:17]=[CH:16][C:15]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=3[C:24]3[N:28](C(C4C=CC=CC=4)(C4C=CC=CC=4)C4C=CC=CC=4)[N:27]=[N:26][N:25]=3)=[CH:14][CH:13]=2)[C:6]=1[C:7]([O:9][CH3:10])=[O:8]>C(O)(=O)C>[NH2:1][C:2]1[N:3]=[C:4]([CH2:48][CH2:49][CH2:50][CH3:51])[N:5]([CH2:11][C:12]2[CH:13]=[CH:14][C:15]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=3[C:24]3[NH:28][N:27]=[N:26][N:25]=3)=[CH:16][CH:17]=2)[C:6]=1[C:7]([O:9][CH3:10])=[O:8]

Participants

3

Reactant 1

HCID 131717066HCID 131717066, compound

Product 1

HCID 178441828HCID 178441828, compoundYield 80%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

To a solution of 47 mg (0.070 mmol) 4-amino-2-butyl-5-carbomethoxy-1-(2'-(N-triphenylmethyltetrazol-5-yl)biphen-4-yl)methylimidazole (Example 1, Step I) in 1 mL glacial acetic acid was added 1 mL distilled water and the mixture stirred at room temperature for 14 hours. All volatiles were removed in vacuo and the residue purified by medium pressure liquid chromatography on silica, eluting with ethyl acetate/acetonitrile/methanol (9:1:.5), to afford 24 mg (0.056 mmol, 79%) of the title compound as a pale yellow powder.

Workup

  1. distillationdistilled water
  2. customAll volatiles were removed in vacuo
  3. customthe residue purified by medium pressure liquid chromatography on silica
  4. washeluting with ethyl acetate/acetonitrile/methanol (9:1:.5)

Sources & evidence

ORD record
ord-cb183a0d83c345338e4758fa4606acae
Source dataset
uspto-grants-1991_11
Patent number
US05064825

Reaction notes

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