HCID 131717066, compound → HCID 178441828, compound

Participants

Reaction Steps

To a solution of 47 mg (0.070 mmol) 4-amino-2-butyl-5-carbomethoxy-1-(2'-(N-triphenylmethyltetrazol-5-yl)biphen-4-yl)methylimidazole (Example 1, Step I) in 1 mL glacial acetic acid was added 1 mL distilled water and the mixture stirred at room temperature for 14 hours. All volatiles were removed in vacuo and the residue purified by medium pressure liquid chromatography on silica, eluting with ethyl acetate/acetonitrile/methanol (9:1:.5), to afford 24 mg (0.056 mmol, 79%) of the title compound as a pale yellow powder.

Provenance & Evidence