HCID 131717068, compound → HCID 178441824, compound

HRID 973669Notes

Reaction equation

HRID 973669 reaction equation
[CH3:1][N:2]([CH3:59])[C:3]1[N:4]=[C:5]([CH2:55][CH2:56][CH2:57][CH3:58])[N:6]([CH2:18][C:19]2[CH:24]=[CH:23][C:22]([C:25]3[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=3[C:31]3[N:35](C(C4C=CC=CC=4)(C4C=CC=CC=4)C4C=CC=CC=4)[N:34]=[N:33][N:32]=3)=[CH:21][CH:20]=2)[C:7]=1[C:8]([O:10]CC1C=CC=CC=1)=[O:9]>CCO.[Pd]>[CH3:1][N:2]([CH3:59])[C:3]1[N:4]=[C:5]([CH2:55][CH2:56][CH2:57][CH3:58])[N:6]([CH2:18][C:19]2[CH:20]=[CH:21][C:22]([C:25]3[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=3[C:31]3[NH:32][N:33]=[N:34][N:35]=3)=[CH:23][CH:24]=2)[C:7]=1[C:8]([OH:10])=[O:9]

Participants

4

Reactant 1

HCID 131717068HCID 131717068, compound

Product 1

HCID 178441824HCID 178441824, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

The title material can be prepared by treating a mixture of 4-(dimethylamino)-2 butyl 5-benzyloxycarbonyl-1-(2'-(N-triphenylmethyltetrazol-5-yl)biphen 4-yl)methylimidazole and 5 weight % of 10% Pd-C with H2 (at 40 psi) in EtOH for 16 hours, followed by filtration (Celite) and purification (SiO2 '35:65:1 CH2Cl2 /MeOH/NH4OH).

Workup

  1. additionby treating
  2. filtrationfollowed by filtration (Celite) and purification (SiO2 '35:65:1 CH2Cl2 /MeOH/NH4OH)

Sources & evidence

ORD record
ord-175d04fc1ab248f7b740feda2197e62a
Source dataset
uspto-grants-1991_11
Patent number
US05064825

Reaction notes

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