Tetrahydrofuran → HCID 19988882, compound

HRID 973680Notes

Reaction equation

HRID 973680 reaction equation
Br[CH2:2][C:3]1[CH:7]=[N:6][N:5]([C:8]2[C:13]([Cl:14])=[CH:12][C:11]([C:15]([F:18])([F:17])[F:16])=[CH:10][C:9]=2[Cl:19])[N:4]=1.[S-:20][C:21]#[N:22].[K+].O1CCCC1>O>[Cl:19][C:9]1[CH:10]=[C:11]([C:15]([F:18])([F:17])[F:16])[CH:12]=[C:13]([Cl:14])[C:8]=1[N:5]1[N:6]=[C:7]([S:20][C:21]#[N:22])[C:3]([CH3:2])=[N:4]1

Participants

5

Reactant 3

HCID 8028TetrahydrofuranHCID 516872Potassium thiocyanateHCID 19778339HCID 19778339, compound

Product 1

HCID 19988882HCID 19988882, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

4-Bromomethyl-2-(2,6-dichloro-4-trifluoromethylphenyl)-2H-1,2,3-triazole (9.55 g), potassium thiocyanate (1 g) and tetrahydrofuran (50 ml) were heated under reflux for 3 hours. The mixture was poured into water, solid collected and recrystallised from ethyl aceteate/hexane to give 2-(2,6-dichloro-4-trifluoromethylphenyl)-4-thiocyanato-methyl-2H-1,2,3-triazole, m.p. 115°-117°. (Compound 23)

Workup

  1. temperatureunder reflux for 3 hours
  2. customcollected
  3. customrecrystallised from ethyl aceteate/hexane

Sources & evidence

ORD record
ord-d3c6adab90bd434bb49980a4019825aa
Source dataset
uspto-grants-1991_11
Patent number
US05064844

Reaction notes

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