Thionyl Chloride → [3-(Trifluoromethyl)phenoxy]acetyl chloride

HRID 973719Notes

Reaction equation

[F:1][C:2]([F:15])([F:14])[C:3]1[CH:4]=[C:5]([CH:11]=[CH:12][CH:13]=1)[O:6][CH2:7][C:8](O)=[O:9].S(Cl)([Cl:18])=O>>[F:1][C:2]([F:15])([F:14])[C:3]1[CH:4]=[C:5]([CH:11]=[CH:12][CH:13]=1)[O:6][CH2:7][C:8]([Cl:18])=[O:9]

Participants

Reactant 2

HCID 24386Thionyl Chloride

HCID 19914302-[3-(Trifluoromethyl)phenoxy]acetic acid

Product 1

HCID 13140641[3-(Trifluoromethyl)phenoxy]acetyl chloride

Procedure

A solution of 6 g of the product of Step B in 36 ml of thionyl chloride was refluxed with stirring for one hour and was evaporated to dryness under reduced pressure to obtain 6.44 g of the desired product which was used as is for the next step.

Workup

customwas evaporated to dryness under reduced pressure

Sources & evidence

ORD record: ord-c09db5187a1f4a44a6e4420e23b35327
Source dataset: uspto-grants-1991_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05064861

Reaction notes

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