Hydrochloric Acid → N-(3-trifluoromethyl phenoxy acetyl)-1,4-diamino-butane hydrochloride

HRID 973721Notes

Reaction equation

HRID 973721 reaction equation
C(OC([NH:8][CH2:9][CH2:10][CH2:11][CH2:12][NH:13][C:14](=[O:27])[CH2:15][O:16][C:17]1[CH:22]=[CH:21][CH:20]=[C:19]([C:23]([F:26])([F:25])[F:24])[CH:18]=1)=O)(C)(C)C.[ClH:28]>C(O)C>[ClH:28].[F:24][C:23]([F:25])([F:26])[C:19]1[CH:18]=[C:17]([CH:22]=[CH:21][CH:20]=1)[O:16][CH2:15][C:14]([NH:13][CH2:12][CH2:11][CH2:10][CH2:9][NH2:8])=[O:27]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 14751511HCID 14751511, compound

Product 1

HCID 14751490N-(3-trifluoromethyl phenoxy acetyl)-1,4-diamino-butane hydrochloride

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 9.8 g of the product of Step D, 90 ml of ethanol and 28 ml of ethanolic 2N hydrogen chloride was refluxed with stirring for one hour and then evaporated to dryness under reduced pressure to obtain 11.9 g of product which was crystallized from ethyl acetate to obtain 7.55 g of the desired product melting at 90° C.

Workup

  1. temperaturewas refluxed
  2. customevaporated to dryness under reduced pressure

Sources & evidence

ORD record
ord-ccf6dc12ed1643ba833ce1b7396b487b
Source dataset
uspto-grants-1991_11
Patent number
US05064861

Reaction notes

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