Hydrochloric Acid → HCID 53999538, compound

HRID 973732Notes

Reaction equation

HRID 973732 reaction equation
[CH2:1]([C:4]1[C:16]([C:17]([F:20])([F:19])[F:18])=[CH:15][CH:14]=[CH:13][C:5]=1[O:6][CH2:7][C:8]([O:10]CC)=[O:9])[CH:2]=[CH2:3].[OH-].[Na+].Cl>C(O)C.O>[CH2:1]([C:4]1[C:16]([C:17]([F:18])([F:19])[F:20])=[CH:15][CH:14]=[CH:13][C:5]=1[O:6][CH2:7][C:8]([OH:10])=[O:9])[CH:2]=[CH2:3]

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 54325132HCID 54325132, compound

Product 1

HCID 53999538HCID 53999538, compoundYield 99.3%

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent

Procedure

8.1 g of the product of Step C in 50 ml of ethanol was stirred for one hour at ambient temperature in the presence of 14 ml of 2N sodium hydroxide and 14 ml of 2N hydrochloric acid were then added with stirring for 15 minutes, followed by concentration to obtain 10.19 g of crude product which was taken up in water. After extracting with methylene chloride and drying, the solvent was evaporated to obtain 7.26 g of the expected product.

Workup

  1. additionwere then added
  2. concentrationfollowed by concentration
  3. customto obtain 10.19 g of crude product which
  4. extractionAfter extracting with methylene chloride
  5. customdrying
  6. customthe solvent was evaporated

Sources & evidence

ORD record
ord-f19c7c0019574cbb8c0a6332cbae511d
Source dataset
uspto-grants-1991_11
Patent number
US05064861

Reaction notes

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