反应详情

温度

25 °C

Methyl 3-cyanocinnamate (42 pw) is added to a mixture of trichloroacetonitrile (194.4 pw) and aluminum bromide (7.2 pw) in the absence of moisture and at about 25° C. Hydrogen chloride is then introduced over a period of 3 hours with stirring, while keeping the temperature constant. Stirring is discontinued, and the mixture is allowed to react further overnight. In this step, too, a constant temperature of 25° C. is maintained. The solidified mixture is dissolved in 800 pw of dichloromethane, washed with water, and the organic phase is dried over sodium sulfate. Evaporation of the solvent gives a white residue, which is recrystallized from methanol or benzene.

1. stirringStirring
2. customto react further overnight
3. washwashed with water
4. dry with materialthe organic phase is dried over sodium sulfate
5. customEvaporation of the solvent
6. customgives a white residue, which
7. customis recrystallized from methanol or benzene