Hydrazine hydrate (1:1) → HCID 178429720, compound

HRID 973837Notes

Reaction equation

HRID 973837 reaction equation
C[O:2][C:3]([C:5]1[N:15]=[C:8]2[N:9]=[C:10]([CH3:14])[CH:11]=[C:12]([SH:13])[N:7]2[N:6]=1)=O.O.[NH2:17][NH2:18]>CO>[NH:17]([C:3]([C:5]1[N:15]=[C:8]2[N:9]=[C:10]([CH3:14])[CH:11]=[C:12]([SH:13])[N:7]2[N:6]=1)=[O:2])[NH2:18]

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 178499048HCID 178499048, compound

Product 1

HCID 178429720HCID 178429720, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a suspension of 2-methoxycarbonyl-7-mercapto-5-methyl-s-triazolo[1,5-a]pyrimidine (10 g) in 200 ml of methanol was dropwise added hydrazine hydrate (110 ml). The mixture was stirred at room temperature for two hours, the insoluble matters were filtered off, and the solvent was removed by distillation from the filtrate. Water (100 ml) was added to the residue and the pH was adjusted to 4.0 with 1N hydrochloric acid. The formed crystals were collected by filtration and washed with 100 ml of water, then with 100 ml of methanol, affording 7.2 g of the objective compound as yellow crystals.

Workup

  1. filtrationthe insoluble matters were filtered off
  2. customthe solvent was removed by distillation from the filtrate
  3. additionWater (100 ml) was added to the residue
  4. filtrationThe formed crystals were collected by filtration
  5. washwashed with 100 ml of water

Sources & evidence

ORD record
ord-7942b747ca8f4711af6d7af39b3870a4
Source dataset
uspto-grants-1991_11
Patent number
US05064953

Reaction notes

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