反应详情

The product obtained in Step 1 of Example 48 (2.5 g) was added to a solution of 1.3 g sodium hydroxide dissolved in 20 ml of water and stirred at room temperature for four hours. The pH of the solution was adjusted to 1-2 with 6N hydrochloric acid. The formed crystals were collected by filtration, washed with 30 ml of water and dried, affording 2.2 g of the objective compound.

1. filtrationThe formed crystals were collected by filtration
2. washwashed with 30 ml of water
3. customdried