Potassium Hydroxide → HCID 178524747, compound

HRID 973862Notes

Reaction equation

HRID 973862 reaction equation
C([O:3][C:4]([C:6]1[C:11](=[O:12])[N:10]2[N:13]=[C:14]([SH:16])[S:15][C:9]2=[N:8][CH:7]=1)=[O:5])C.[OH-].[K+]>O>[C:4]([C:6]1[C:11](=[O:12])[N:10]2[N:13]=[C:14]([SH:16])[S:15][C:9]2=[N:8][CH:7]=1)([OH:5])=[O:3]

Participants

4

Reactant 2

HCID 14797Potassium HydroxideHCID 178469720HCID 178469720, compound

Product 1

HCID 178524747HCID 178524747, compoundYield 80.2%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
60 °C

Procedure

The product obtained in Step 1 (9.1 g) was added to a solution of 4.0 g of potassium hydroxide in 200 ml of water, and the mixture was heated at 60° C. for 30 minutes. After cooling to room temperature, the solution was washed with 200 ml of ethyl acetate and the pH was adjusted to 1.0 with hydrochloric acid. The formed crystals were collected by filtration and washed with ether, affording 6.5 g of the objective compound.

Workup

  1. temperatureAfter cooling to room temperature
  2. washthe solution was washed with 200 ml of ethyl acetate
  3. filtrationThe formed crystals were collected by filtration
  4. washwashed with ether

Sources & evidence

ORD record
ord-b55e880e1ef24811b7c01511e0c9f08a
Source dataset
uspto-grants-1991_11
Patent number
US05064953

Reaction notes

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