反应详情

温度

5 °C

To 70 ml of an acetonitrile solution containing 21 g of 6-chloro-1,3-dimethyluracil thus-obtained was added 16 g of N-chlorosuccinimide under cooling with ice (at the solution temperature of 5° C). The temperature was gradually raised to 35° C. After further stirring for 1 hour, 70 ml of water was added to the reaction solution, and the crystals thus-deposited were collected by filtration, washed with a cold solvent mixture of 18 ml of acetonitrile and 18 ml of water and dried to obtain 18 g of 5,6-dichloro-1,3-dimethyluracil.

1. customthus-obtained
2. temperatureThe temperature was gradually raised to 35° C
3. filtrationthe crystals thus-deposited were collected by filtration
4. washwashed with a cold solvent mixture of 18 ml of acetonitrile and 18 ml of water
5. customdried