反应详情

85.3 g of 2-amino-4-chlorobenzamide obtained in Step (1) was dissolved in 350 ml of pyridine, and to the resulting solution, while maintaining it at 10° to 20° C., there was added dropwise 92 g of phosphorus oxychloride. After being reacted at room temperature for 1 hour, the reaction mixture was poured into ice water. The crystals thus-deposited were collected by filtration, washed with water and dried. Yield: 39 g (51.1%).

1. temperatureto the resulting solution, while maintaining it at 10° to 20° C.
2. customAfter being reacted at room temperature for 1 hour
3. filtrationThe crystals thus-deposited were collected by filtration
4. washwashed with water
5. customdried