Nitric Acid → HCID 19987116, compound

HRID 973917Notes

Reaction equation

HRID 973917 reaction equation
[C:1]([NH:4][C:5]1[CH:12]=[C:11]([Cl:13])[CH:10]=[CH:9][C:6]=1[C:7]#[N:8])(=[O:3])[CH3:2].[N+:14]([O-])([OH:16])=[O:15]>>[C:1]([NH:4][C:5]1[CH:12]=[C:11]([Cl:13])[C:10]([N+:14]([O-:16])=[O:15])=[CH:9][C:6]=1[C:7]#[N:8])(=[O:3])[CH3:2]

Participants

3

Reactant 2

HCID 944Nitric AcidHCID 19360204HCID 19360204, compound

Product 1

HCID 19987116HCID 19987116, compound

Conditions

Temperature
0 °C

Procedure

25 g of 2-acetylamino-4-chlorobenzonitrile obtained in Step (3) above was added little by little to 200 ml of fuming nitric acid which had been cooled at 0° C. After the completion of the addition, the mixture was reacted for 30 minutes, and then the reaction solution was poured into 1 liter of ice water. The crystals thus-deposited were collected by filtration, washed thoroughly with water and dried. Yield: 22.2 g (72.4%).

Workup

  1. additionAfter the completion of the addition
  2. customthe mixture was reacted for 30 minutes
  3. filtrationThe crystals thus-deposited were collected by filtration
  4. washwashed thoroughly with water
  5. customdried

Sources & evidence

ORD record
ord-3087a3912f364afe85e43237322f45c3
Source dataset
uspto-grants-1991_11
Patent number
US05066577

Reaction notes

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