Hydrochloric Acid → HCID 54161563, compound

HRID 973938Notes

Reaction equation

HRID 973938 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C@@H:9]([CH3:15])[CH2:10][C:11](=[O:14])[NH:12][N:13]=2)=[CH:4][CH:3]=1.O1[CH:21]=[CH:20][C:19](=[O:22])[CH:18]=[CH:17]1.Cl>O>[CH3:15][C@@H:9]1[C:8]([C:5]2[CH:6]=[CH:7][C:2]([N:1]3[CH:21]=[CH:20][C:19](=[O:22])[CH:18]=[CH:17]3)=[CH:3][CH:4]=2)=[N:13][NH:12][C:11](=[O:14])[CH2:10]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 79684H-pyran-4-oneHCID 11745737(S)-3(2h)-Pyridazinone, 6-(4-Aminophenyl)-4,5-Dihydro-5-Methyl-

Product 1

HCID 54161563HCID 54161563, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture of (S)-6-(4-aminophenyl)-5-methyl-4,5-dihydro-3(2H)-pyridazinone (147 mg), 4H-pyran-4-one (78 mg) and hydrochloric acid (0.1 N, 1.5 ml) in water (2 ml) was stirred under reflux under nitrogen for 3 hours. The reaction mixture was cooled to afford the title compound, which was collected, washed with water and dried, 110 mg, m.p. 256-7° C. (softens 80° C.), [α]25D=+ 354° (1.03% in dimethylformamide).

Workup

  1. temperatureunder reflux under nitrogen for 3 hours
  2. temperatureThe reaction mixture was cooled

Sources & evidence

ORD record
ord-2a4530d46509450baa06c895b7ccf9ae
Source dataset
uspto-grants-1991_11
Patent number
US05066653

Reaction notes

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