反应详情

A mixture of 6-(4-aminophenyl)-5-methyl-4,5-dihydro -3(2H)-pyridazinone (101 mg), 1,5-bis(dimethylamino)-1,4-pentadien-3-one (84 mg) and hydrochloric acid (1N, 0.5 ml) in water (1.5 ml) was stirred at room temperature for 4 hours. More hydrochloric acid (1N, 0.5 ml) was added and the reaction mixture was stirred at room temperature for 18 hours and then under reflux for 4 hours to afford a quantity of red insoluble material. The hot aqueous solvent was decanted off from the insoluble material, was allowed to cool and was seeded to afford the title compound, 41 mg, m.p. 245-249° C.

1. stirringthe reaction mixture was stirred at room temperature for 18 hours
2. temperatureunder reflux for 4 hours
3. customto afford a quantity of red insoluble material
4. customThe hot aqueous solvent was decanted off from the insoluble material
5. temperatureto cool