HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → HCID 14479949, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 2,6-Di-tert-butyl-4-mercaptophenol | HCID 70370 | — |
| Reactant | 2-Bromopropanoyl chloride | HCID 97980 | — |
| Reactant | Ethanone, 2-amino-1-phenyl-, hydrochloride (1:1) | HCID 2723597 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 14479949 | HCID 14479949 | — |
Reaction Steps
2-Bromopropionyl chloride (5 mmole) is added to a cold (5° C.) solution of 2-aminoacetophenone hydrochloride (5 mmole) in methylene chloride followed by 14 ml of triethylamine in methylene chloride. The mixture is stirred at room temperature. After about 1 hour, the product of Example 2 is added and the solution heated to reflux. The mixture is allowed to cool to room temperature. The reaction mixture is treated as in Example 3 to produce 2-[[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]thio]-N-(2-oxo-2-phenylethyl)propanamide.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05066679 |
| Source dataset | uspto-grants-1991_11 |
| ORD ID | ord-688bb3affea8437e9eee2540d4852d66 |
| Source note | uspto-grants-1991_11 |