Water → HCID 136176257, compound

HRID 973979Notes

Reaction equation

HRID 973979 reaction equation
[OH:1][C:2]1[CH:15]=[C:14]([O:16][CH3:17])[CH:13]=[CH:12][C:3]=1[C:4]([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)=O.[N:18]1[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=1[C:24]([NH:26][NH2:27])=[O:25].O>CN1CCCC1=O>[N:18]1[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=1[C:24]([NH:26][N:27]=[C:4]([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)[C:3]1[CH:12]=[CH:13][C:14]([O:16][CH3:17])=[CH:15][C:2]=1[OH:1])=[O:25]

Participants

5

Reactant 3

HCID 962WaterHCID 46322-Hydroxy-4-methoxybenzophenoneHCID 255881Picolinohydrazide

Product 1

HCID 136176257HCID 136176257, compoundYield 81.8%

Reagents, catalysts & solvents 1

HCID 13387N-methyl-2-pyrrolidoneSolvent

Procedure

47.0 g of 2-hydroxy-4-methoxybenzophenone and 27.7 g of picolinic acid hydrazide are stirred in 150 ml of N-methylpyrrolidone for 18 hours at 140° C. After the reaction mixture has cooled to room temperature, the brownish yellow solution is treated with 200 ml of water. The precipitate produced is isolated by filtration and washed with isopropanol and then with water. After the product has been dried under vacuum at 50°-60° C., 57.4 g of 2-hydroxy-4-methoxybenzophenone picolinoylhydrazone are obtained.

Workup

  1. customThe precipitate produced
  2. customis isolated by filtration
  3. washwashed with isopropanol
  4. customAfter the product has been dried under vacuum at 50°-60° C.

Sources & evidence

ORD record
ord-798aacf1490442c4b5c22246c1ef39f8
Source dataset
uspto-grants-1991_11
Patent number
US05066695

Reaction notes

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