Hydrochloric Acid → HCID 19775483, compound

HRID 973989Notes

Reaction equation

HRID 973989 reaction equation
[CH3:1][N:2]([CH3:24])[CH2:3][C:4]#[C:5][CH2:6][NH:7][C:8](=[O:23])[C:9]([OH:22])([C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1.[ClH:25]>CO>[ClH:25].[CH3:24][N:2]([CH3:1])[CH2:3][C:4]#[C:5][CH2:6][NH:7][C:8](=[O:23])[C:9]([OH:22])([C:16]1[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=1)[C:10]1[CH:11]=[CH:12][CH:13]=[CH:14][CH:15]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 14931313HCID 14931313, compound

Product 1

HCID 19775483HCID 19775483, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of N-(4-dimethylamino-2-butynyl)-2-hydroxy-2,2-diphenylacetamide (0.35 g) in methanol (5 ml) was added 6.4N methanolic hydrogen chloride (3ml) and the solution was evaporated in vacuo. The residue was dissolved in chloroform and the solution was evaporated in vacuo. The oily residue was crystallized from a mixture of isopropyl alcohol and ethyl acetate to give N-(4-dimethylamino-2-butynyl)-2-hydroxy-2,2-diphenylacetamide hydrochloride (0.21 g).

Workup

  1. customthe solution was evaporated in vacuo
  2. dissolutionThe residue was dissolved in chloroform
  3. customthe solution was evaporated in vacuo
  4. customThe oily residue was crystallized from a mixture of isopropyl alcohol and ethyl acetate

Sources & evidence

ORD record
ord-5c485b56720241328e69bc5928e4612f
Source dataset
uspto-grants-1991_11
Patent number
US05066680

Reaction notes

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