Phosgene → HCID 15675485, compound

HRID 974023Notes

Reaction equation

HRID 974023 reaction equation
Cl.[C:2]1([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH:7]=[CH:6][C:5]([O:8][CH2:9][CH2:10][NH2:11])=[CH:4][CH:3]=1.[C:18](Cl)(Cl)=[O:19].[CH3:22][NH:23][OH:24]>>[C:2]1([C:12]2[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=2)[CH:3]=[CH:4][C:5]([O:8][CH2:9][CH2:10][NH:11][C:18]([N:23]([OH:24])[CH3:22])=[O:19])=[CH:6][CH:7]=1

Participants

4

Reactant 3

HCID 6371PhosgeneHCID 11647MethylhydroxylamineHCID 17131188HCID 17131188, compound

Product 1

HCID 15675485HCID 15675485, compound

Procedure

This hydrochloride was converted to the title compound by treatment with phosgene and N-methylhydroxylamine as in Example 32 above. Recrystallization from methanol-water provided a white powder (0.46 g, 25% yield), mp 178°-179° C. (dec).

Sources & evidence

ORD record
ord-13983080390d40d88ea15a5fe6d79a75
Source dataset
uspto-grants-1991_11
Patent number
US05066658

Reaction notes

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