Hydrochloric Acid → 2-(o-Toluidino)-5-(4-(piperazin-1-yl)phenyl)oxazole-4-carboxamide

HRID 97410Notes

Reaction equation

HRID 97410 reaction equation
[CH3:46][OH:47].[Cl:43][CH2:44][Cl:45].[ClH:36].[O:37]1[CH2:38][CH2:39][O:40][CH2:41][CH2:42]1.[c:1]1([CH3:35])[c:2]([NH:7][c:8]2[o:9][c:10](-[c:16]3[cH:17][cH:18][c:19]([N:22]4[CH2:23][CH2:24][N:25]([C:28]([O:29][C:30]([CH3:31])([CH3:32])[CH3:33])=[O:34])[CH2:26][CH2:27]4)[cH:20][cH:21]3)[c:11]([C:13]([NH2:14])=[O:15])[n:12]2)[cH:3][cH:4][cH:5][cH:6]1>>[c:1]1([CH3:35])[c:2]([NH:7][c:8]2[o:9][c:10](-[c:16]3[cH:17][cH:18][c:19]([N:22]4[CH2:23][CH2:24][NH:25][CH2:26][CH2:27]4)[cH:20][cH:21]3)[c:11]([C:13]([NH2:14])=[O:15])[n:12]2)[cH:3][cH:4][cH:5][cH:6]1

Participants

6

Reactant 5

HCID 313Hydrochloric AcidHCID 887MethanolHCID 6344DichloromethaneHCID 312751,4-DioxaneHCID 59587624Tert-butyl 4-(4-(2-(o-toluidino)-4-carbamoyloxazol-5-yl)phenyl)piperazine-1-carboxylate

Product 1

HCID 595874062-(o-Toluidino)-5-(4-(piperazin-1-yl)phenyl)oxazole-4-carboxamide

Sources & evidence

ORD record
ord-e9ef6c5b2bf3417b93a93c179147c939
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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