反应详情

A mixture of 196.2 g of 3,4,5-trimethoxybenzaldehyde, 127.3 g of trimethoxymethane, 200 ml of methanol and 0.1 g of hydrochloric acid is refluxed for 3 hours. After cooling the reaction mixture, 0.2 g of a 24% sodium methoxide solution in methanol is added thereto and the mixture is evaporated under reduced pressure to remove solvent. 150 ml of tetrahydrofuran are added to the residue, and the mixture is evaporated under reduced pressure to remove solvent. 243 g of 3,4,5-trimethoxybenzaldehyde dimethyl acetal are thereby obtained as a pale yellow oil.

1. temperatureis refluxed for 3 hours
2. additionis added
3. customthe mixture is evaporated under reduced pressure
4. customto remove solvent
5. addition150 ml of tetrahydrofuran are added to the residue
6. customthe mixture is evaporated under reduced pressure
7. customto remove solvent