Hydrochloric Acid → HCID 54005848, compound

HRID 974129Notes

Reaction equation

HRID 974129 reaction equation
[N:1]1([CH2:7][CH:8]2[CH2:13][NH:12][C:11]3[CH:14]=[CH:15][CH:16]=[CH:17][C:10]=3[O:9]2)[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.Cl.[N:19]([O-])=[O:20].[Na+]>O>[N:1]1([CH2:7][CH:8]2[CH2:13][N:12]([N:19]=[O:20])[C:11]3[CH:14]=[CH:15][CH:16]=[CH:17][C:10]=3[O:9]2)[CH2:2][CH2:3][O:4][CH2:5][CH2:6]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 23668193Sodium NitriteHCID 43199397HCID 43199397, compound

Product 1

HCID 54005848HCID 54005848, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Similarly 8 g (0.034 mole) of racemic 2-(4-morpholinylmethyl)-3,4-dihydro-2H-1,4-benzoxazine in about 130 ml. of 2N aqueous hydrochloric acid was treated with 1.3 g (0.019 mole) of sodium nitrite in about 100 ml of water at 0° C. to produce racemic 2-(4-morpholinylmethyl)-4-nitroso-3,4-dihydro-2H-1,4-benzoxazine, which was used as such in the next synthetic step without further purification or characterization.

Sources & evidence

ORD record
ord-1d7333aaaa814d5fb9caecb6c5f3ca67
Source dataset
uspto-grants-1991_11
Patent number
US05066803

Reaction notes

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