Water → HCID 14817089, compound

HRID 974149Notes

Reaction equation

HRID 974149 reaction equation
[CH2:1]1[O:3][CH2:2]1.[NH2:4][C:5]1[CH:10]=[C:9]([C:11]([F:14])([F:13])[F:12])[C:8]([NH2:15])=[CH:7][C:6]=1[N+:16]([O-:18])=[O:17].O>COCCOC>[NH2:4][C:5]1[CH:10]=[C:9]([C:11]([F:14])([F:13])[F:12])[C:8]([NH:15][CH2:2][CH2:1][OH:3])=[CH:7][C:6]=1[N+:16]([O-:18])=[O:17]

Participants

5

Reactant 3

HCID 962WaterHCID 6354Ethylene OxideHCID 14817088HCID 14817088, compound

Product 1

HCID 14817089HCID 14817089, compound

Reagents, catalysts & solvents 1

HCID 80711,2-DimethoxyethaneSolvent

Procedure

Ethylene oxide is passed in portions into a mixture of 2.2 g (10 mmol) of 1,4-diamino-2-nitro-5-trifluoromethylbenzene, 25 ml of water and 10 ml of monoethylene glycol dimethyl ether at 60° C. in the course of 20 minutes, and the reaction is monitored by thin layer chromatography. When the monohydroxyethylation is complete, the mixture is cooled slowly to room temperature and the precipitate is filtered off and washed with water.

Workup

  1. filtrationthe precipitate is filtered off
  2. washwashed with water

Sources & evidence

ORD record
ord-dc029ff9f82e4d55851dd680cf7168bc
Source dataset
uspto-grants-1991_11
Patent number
US05067967

Reaction notes

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