Water → HCID 14817089, compound

Participants

Reaction Steps

Ethylene oxide is passed in portions into a mixture of 2.2 g (10 mmol) of 1,4-diamino-2-nitro-5-trifluoromethylbenzene, 25 ml of water and 10 ml of monoethylene glycol dimethyl ether at 60° C. in the course of 20 minutes, and the reaction is monitored by thin layer chromatography. When the monohydroxyethylation is complete, the mixture is cooled slowly to room temperature and the precipitate is filtered off and washed with water.

Provenance & Evidence