Potassium → HCID 14856061, compound

HRID 974273Notes

Reaction equation

HRID 974273 reaction equation
[Br:1][C:2]1[C:7](=[O:8])[C:6]([O:9][CH2:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=[CH:5][N:4](CC2C=CC=CC=2)[C:3]=1[C:24]([O:26]CC1C=CC=CC=1)=[O:25].[K]>O1CCCC1.O>[Br:1][C:2]1[C:3]([C:24]([OH:26])=[O:25])=[N:4][CH:5]=[C:6]([O:9][CH2:10][C:11]2[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=2)[C:7]=1[O:8][CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1

Participants

5

Reactant 2

HCID 5462222PotassiumHCID 14856059HCID 14856059, compound

Product 1

HCID 14856061HCID 14856061, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 8028TetrahydrofuranSolvent

Procedure

3.8 g of 3-Bromo-1,4-dihydro-4-oxo-5-(phenylmethoxy)-1-(phenylmethyl)-2-pyridinecarboxylic acid, phenylmethyl ester and 0.54 g potassium hydroxyde were dissolved in 30 ml tetrahydrofuran and 3 ml H2O. After stirring for 24 hours at room temperature, the THF was distilled off and 20 ml H2O were added to the residue. The pH was adjusted to 3.5 with 2NHCl. Crystals of the title compound were formed and filtered off, washed with 20 ml H2O and dried; yield 3 g of the title compound white crystals.

Workup

  1. distillationthe THF was distilled off
  2. addition20 ml H2O were added to the residue

Sources & evidence

ORD record
ord-ccabfc69f1ed46f1a6cf9ec48919b3ae
Source dataset
uspto-grants-1991_11
Patent number
US05068331

Reaction notes

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