Diethyl Ether → HCID 54477943, compound

HRID 974300Notes

Reaction equation

HRID 974300 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:10]=[CH:11][C:12]=1[O:13][CH3:14])[CH:6]=[CH:7][CH2:8]Cl.[NH2:15][C:16]1[S:17][C:18]2[CH2:19][CH2:20][NH:21][CH2:22][CH2:23][C:24]=2[N:25]=1.CCOCC>C(Cl)(Cl)Cl>[NH2:15][C:16]1[S:17][C:18]2[CH2:19][CH2:20][N:21]([CH2:8][CH:7]=[CH:6][C:5]3[CH:10]=[CH:11][C:12]([O:13][CH3:14])=[C:3]([O:2][CH3:1])[CH:4]=3)[CH2:22][CH2:23][C:24]=2[N:25]=1

Participants

5

Reactant 3

HCID 3283Diethyl EtherHCID 199857852-Amino-4,5,6,7,8-pentahydrothiazolo[5,4-d]azepineHCID 544819304-(3-Chloroprop-1-en-1-yl)-1,2-dimethoxybenzene

Product 1

HCID 54477943HCID 54477943, compoundYield 7.7%

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

Prepared from 3,4-dimethoxy-cinnamyl chloride (prepared at -5° C. for 10 minutes) and 2 equivalents of 2-amino-4,5,7,8-tetrahydro-6H-thiazolo[5,4-d]azepine in chloroform. Yield: 7.7% of theory, Melting point: 122°-126° C. (ether).

Sources & evidence

ORD record
ord-deeee94051c5410b8b38745d98536009
Source dataset
uspto-grants-1991_11
Patent number
US05068325

Reaction notes

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