2-Amino-4,5,6,7,8-pentahydrothiazolo[5,4-d]azepine → HCID 73668870, compound

HRID 974302Notes

Reaction equation

HRID 974302 reaction equation
[C:1]1([CH:11]=[CH:12][CH2:13]Cl)[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][CH:2]=1.[NH2:15][C:16]1[S:17][C:18]2[CH2:19][CH2:20][NH:21][CH2:22][CH2:23][C:24]=2[N:25]=1.C(Cl)(Cl)Cl.CO>C(Cl)(Cl)Cl>[NH2:15][C:16]1[S:17][C:18]2[CH2:19][CH2:20][N:21]([CH2:13][CH:12]=[CH:11][C:1]3[C:10]4[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=4)[CH:4]=[CH:3][CH:2]=3)[CH2:22][CH2:23][C:24]=2[N:25]=1

Participants

5

Reactant 3

HCID 199857852-Amino-4,5,6,7,8-pentahydrothiazolo[5,4-d]azepineHCID 21584188Chloroform methanolHCID 54441900HCID 54441900, compound

Product 1

HCID 73668870HCID 73668870, compoundYield 31%

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

Prepared from 3-(1-naphthyl)allyl chloride and 2 equivalents of 2-amino-4,5,7,8-tetrahydro-6 H-thiazolo[5,4-d]azepine in chloroform for 3 days at 20° C. Yield: 31% of theory, Melting point: 178°-180° C. (chloroform/methanol =100:1).

Sources & evidence

ORD record
ord-ef718ec902a045d194cd9221b549206e
Source dataset
uspto-grants-1991_11
Patent number
US05068325

Reaction notes

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