Diethyl Ether → HCID 53732315, compound

HRID 974304Notes

Reaction equation

HRID 974304 reaction equation
[CH2:1]([O:8][C:9]1[CH:18]=[CH:17][CH:16]=[CH:15][C:10]=1[CH:11]=[CH:12][CH2:13]Cl)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH2:19][C:20]1[S:21][C:22]2[CH2:23][CH2:24][NH:25][CH2:26][CH2:27][C:28]=2[N:29]=1.CCOCC>C(Cl)(Cl)Cl>[NH2:19][C:20]1[S:21][C:22]2[CH2:23][CH2:24][N:25]([CH2:13][CH:12]=[CH:11][C:10]3[CH:15]=[CH:16][CH:17]=[CH:18][C:9]=3[O:8][CH2:1][C:2]3[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=3)[CH2:26][CH2:27][C:28]=2[N:29]=1

Participants

5

Reactant 3

HCID 3283Diethyl EtherHCID 199857852-Amino-4,5,6,7,8-pentahydrothiazolo[5,4-d]azepineHCID 53940112HCID 53940112, compound

Product 1

HCID 53732315HCID 53732315, compoundYield 36%

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

Prepared from 2-benzyloxy-cinnamyl chloride and 2 equivalents of 2-amino-4,5,7,8-tetrahydro-6 H-thiazolo[5,4-d]azepine in chloroform for 5 hours at 50° C. Yield: 36% of theory, Melting point: 103°-107° C. (ether).

Sources & evidence

ORD record
ord-1aec29d0c35e453699581ae94d337cf4
Source dataset
uspto-grants-1991_11
Patent number
US05068325

Reaction notes

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